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KMID : 1130320190620040126
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Korean Journal of Pediatrics
2019 Volume.62 No. 4 p.126 ~ p.130
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The association between preeclampsia and autism spectrum disorders among children: a meta-analysis
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Jenabi Ensiyeh
Karami Manoochehr
Khazaei Salman
Bashirian Saeid
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Abstract
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Purpose: This meta-analysis pooled relevant case-control and cohort studies to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.
Methods: The search for relevant studies in major databases was performed, which included Web of Science, PubMed, and Scopus up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among the studies.
Results: The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD (OR, 1.36; 95% CI, 1.12?1.60) and (RR, 1.30; 95% CI, 1.20?1.41).
Conclusions: Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.
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KEYWORD
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Autism spectrum disorder, Autism, Preeclampsia, Pregnancy
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